A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
نویسندگان
چکیده
منابع مشابه
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point of these pathways. Here, we show that cholesterol sele...
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Department of Pediatrics, Division of Newborn Medicine, Los Angeles County+University of Southern California Medical Center and Children’s Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA 90033, USA; Excellence Cluster CardioPulmonary System (ECCPS), D-35392 Giessen, Hessen, Germany; Member of the German Center for Lung Research, Department of Internal Medicine II, Universi...
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ژورنال
عنوان ژورنال: Nature
سال: 2013
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature12631